Where there is no evidence: implementing family interventions from recommendations in the NICE guideline 11 on challenging behaviour in a South African health service for adults with intellectual disability

Abstract Background Low- and middle-income countries often lack the fiscal, infrastructural and human resources to conduct evidence-based research; similar constraints may also hinder the application of good clinical practice guidelines based on research findings from high-income countries.While the context of health organizations is increasingly r

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Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

Sophisticated mechanisms that preserve genome integrity are critical to ensure the maintenance of regenerative capacity while preventing transformation of somatic Lip Treatment stem cells (SCs), yet little is known about mechanisms regulating genome maintenance in these cells.Here, we show that intestinal stem cells (ISCs) induce the Argonaute fami

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